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应用电液动力学方法形成微液滴是目前非连续药物传输微系统发展中的关键问题.本文介绍了一种基于电液动力学原理,可有效形成微液滴的药物传输系统.系统参数包括:外加电场1 500 V,两电极距离100μm,针管内径20μm,整体体积为2 mm×2 mm×3 mm.基于微电液动力学原理、微流体效应、带电颗粒中和和药品物理性质,详细分析了微液滴的形成过程,理论计算出微液滴的尺寸和形成时间.根据设计,需要8.5 ms可形成体积为2.83 nL的微小液滴.此项研究提供了一种基于电液动力学方法的可重复、稳定、可控地形成微流体的药物传输微系统.
The formation of micro-droplets using electro-hydrodynamic method is the key issue in the current development of non-continuous drug delivery micro-systems.In this paper, a drug delivery system based on the principle of electro-hydraulics is introduced to effectively form micro-droplets.The system parameters include : External electric field 1 500 V, distance between two electrodes 100 μm, inner diameter of needle 20 μm, overall volume 2 mm × 2 mm × 3 mm Based on micro-electrohydrodynamic principles, microfluidic effect, neutralization of charged particles and physical properties of drug The formation of the microdroplets was analyzed and the size and formation time of the microdroplets was theoretically calculated.According to the design, it takes 8.5 ms to form microdroplets with a volume of 2.83 nL.This study provides a method based on electrohydrodynamics The method reproducibly, stably and controllably forms a microfluidic drug delivery microsystem.