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目的探讨B7-H4表达水平可否作为早期诊断宫颈癌、评估宫颈癌浸润深度和淋巴转移状态、预测宫颈癌预后的有效指标。方法选择56例宫颈癌患者做为观察组,52例健康体检者做为对照组。用ELISA夹心法检测血清B7-H4水平,并比较术前、术后血清中B7-H4水平的改变。结果与对照组比较,观察组血清B7-H4水平明显增高,差异有显著统计学意义(P<0.05);观察组术后血清B7-H4水平明显降低,差异有显著统计学意义(P<0.05)。结论血清B7-H4水平在宫颈癌发生、发展、评估、发现早期复发等方面具有显著的临床价值和实用价值。
Objective To investigate whether B7-H4 expression can be used as an effective marker for early diagnosis of cervical cancer, assessing the depth of invasion and lymph node metastasis of cervical cancer and predicting the prognosis of cervical cancer. Methods Fifty-six patients with cervical cancer were selected as observation group and 52 healthy subjects as control group. Serum B7-H4 level was detected by ELISA sandwich method, and the changes of B7-H4 level in serum before and after surgery were compared. Results Compared with the control group, the level of serum B7-H4 in the observation group was significantly increased (P <0.05); the level of serum B7-H4 in the observation group decreased significantly after the operation, with significant difference (P <0.05 ). Conclusion Serum B7-H4 levels have significant clinical value and practical value in the occurrence, development, evaluation and early recurrence of cervical cancer.