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目的探讨脑梗死急性期s100蛋白的变化及对预后的价值。方法 40例脑梗死急性期患者为研究组,对照组为同期40例健康检查的中老年人群。对比两组血压、血糖、血脂[总胆固醇(TC)、甘油三酯(TG)]水平及s100蛋白浓度;研究组中死亡患者与未死亡患者s100蛋白浓度。结果研究组入院时、入院72 h、入院1周s100蛋白水平均明显高于对照组,研究组s100蛋白水平以入院72 h表达最高(P<0.05)。研究组中死亡患者入院时、入院72 h、入院1周s100蛋白水平分别为(0.153±0.058)、(0.265±0.085)、(0.203±0.081)ng/ml低于未死亡患者的(0.178±0.063)、(0.316±0.099)、(0.268±0.074)ng/ml(P<0.05)。结论 s100蛋白随脑梗死的病情进展出现变化,可作为判断治疗疗效及患者预后的实验室标志物。
Objective To investigate the changes of s100 protein in acute stage of cerebral infarction and its prognostic value. Methods Forty patients with acute cerebral infarction were selected as the study group and the control group as 40 middle-aged and elderly patients with the same period of health examination. The levels of blood pressure, blood glucose, blood lipids [total cholesterol (TC), triglyceride (TG)] and s100 protein concentration in the two groups were compared. The s100 protein concentrations in the death and non-death groups in the study group were compared. Results At study admission, the serum levels of s100 at admission 72 h and admission 1 week were significantly higher than those in the control group. The level of s100 protein in the study group was the highest at 72 h after admission (P <0.05). At study admission, the serum levels of s100 protein at admission 72 h after admission were (0.153 ± 0.058), (0.265 ± 0.085), (0.203 ± 0.081) ng / ml, respectively, lower than those in patients without death (0.178 ± 0.063 ), (0.316 ± 0.099) and (0.268 ± 0.074) ng / ml respectively (P <0.05). Conclusion The s100 protein changes with the progress of cerebral infarction, which can be used as laboratory markers to judge the curative effect and prognosis of patients.