论文部分内容阅读
晕动病是一种临床常见病。迄今,治疗晕动导致恶心,呕吐的首选药物—东莨菪硷有时会伴随着种种讨厌的副作用。这些副作用是由于口服给药(冲击释放)无法预测的血药浓度所引起的。一种新型的药物释放方式—透皮治疗方式(TTS)已经问世,其商品名为Transderm—V. TTS以恒定的速度透过皮肤释放东莨菪硷。这种方法可允许半衰期很短的药物得以延期供药,从而使血药浓度维持在规定的治疗水平。这种方法消除了频繁给药的必要性,并把与传统的药物剂型有关的副作用减少到最低限度。使病人乐于接受。
Motion sickness is a common clinical disease. To date, scopolamine, the drug of choice for the treatment of nausea and vomiting, has sometimes been accompanied by nasty side effects. These side effects are due to unpredictable plasma concentrations due to oral administration (shock release). A New Drug Delivery Approach - Transdermal Therapy (TTS) has been introduced under the trade name Transderm-V. TTS delivers scopolamine at a constant rate across the skin. This method allows drugs with short half-lives to be delayed for drug delivery, thus maintaining the plasma concentration at the prescribed level of treatment. This method eliminates the need for frequent dosing and minimizes the side effects associated with traditional pharmaceutical dosage forms. Make the patient happy to accept.