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目的了解用于阴道黏膜消毒产品的毒性,以评价其使用安全性。方法采用动物试验方法,对41种用于黏膜消毒产品的毒性进行了评价。结果主要成分为碘伏类、醋酸洗必泰、季铵盐类、中草药和其他类的41个消毒产品,在急性经口毒性试验观察期内,均未发现试验动物有明显中毒反应,试验动物解剖未发现组织和脏器有异常病变。所试验的41种用于黏膜消毒的产品小鼠急性经口LD50均>5000 mg/kg体重,属实际无毒级。阴道黏膜刺激试验,碘伏类产品通过率为86.7%;醋酸氯己定类产品通过率为72.7%;季铵盐类产品通过率为83.3%;含中草药的产品通过率为80.0%;其他类产品通过率为75.0%。结论大部分用于阴道黏膜的产品属实际无毒级,较为安全。
Objective To understand the toxicity of vaginal mucosal disinfection products to evaluate its safety. Methods The animal test methods were used to evaluate the toxicity of 41 kinds of disinfection products for mucosa. The results of the main components of iodine, chlorhexidine acetate, quaternary ammonium salts, herbs and other 41 kinds of disinfection products in the acute oral toxicity test observed period, were found no significant experimental animals poisoning reaction, experimental animals Anatomy did not find abnormal tissue and organ lesions. The 41 products tested for mucosal disinfection of mice with acute oral LD50 were> 5000 mg / kg body weight, which is actually non-toxic grade. Vaginal mucosal irritation test showed that the passing rate of iodophor products was 86.7%; the passing rate of chlorhexidine acetate products was 72.7%; the pass rate of quaternary ammonium products was 83.3%; the passing rate of products containing Chinese herbal medicines was 80.0%; other types Product pass rate was 75.0%. Conclusion Most of the products used for vaginal mucosa are actually non-toxic grade, safer.