肝纤维化是当前国内外关于慢性肝病的研究热点与难点,对其发生机制已有所认识,但临床治疗方面仍欠缺突破性的方案。在国外学者看来最好的抗纤维化策略是减少或抑制潜在疾病,对于不同原因造成的肝病需要不同的药物治疗。我国目前对干扰素及核苷(酸)的抗病毒及抗纤维化作用研究较多,并且我国具有独特的祖国医学及前人经验,中药单方及复方制剂研究及应用较多,中西药联合治疗有效的报道很多,其作用机制还有待进一步研究。 Hepatic fibrosis is a hot and difficult issue in the field of chronic liver disease both at home and abroad. Although its mechanism has been recognized, there is still a lack of breakthrough in clinical treatment. The best antifibrosis strategy in the eyes of foreign scholars is to reduce or inhibit potential diseases, and require different drug treatments for liver diseases caused by different causes. At present, there are many studies on the anti-virus and anti-fibrosis effects of interferon and nucleoside (acid) in our country, and our country has a unique experience of the motherland medicine and its predecessors. There are many studies and applications of traditional Chinese medicine There are many effective reports and its mechanism remains to be further studied.