给猪腹腔注射6-氨基烟酰胺诱发了一种综合征:类似于在昆士兰发现的一种天然的疾病。局灶性损害主要包括:发生于脊髓颈、腰膨大部中央灰质神经胶质细胞的破坏。脊髓灰质广泛的空泡形成和丧失的神经胶质细胞的修复。作者们设想:如果一种抗烟酰胺代谢产物的阈量被机体吸收,在短期内将会发生天然的急性烟酰胺缺乏症。 Intraperitoneal injection of 6-aminonicotinic acid into the pig induces a syndrome similar to a natural disease found in Queensland. Focal lesions include: occurred in the spinal cord neck, central lumbar enlargement of central gray matter glial cell damage. Extensive cavitation of spinal cord formation and loss of glial cells repair. The authors envisage that if a threshold amount of an anti-nicotinamide metabolite is taken up by the body, a natural acute niacinamide deficiency will occur in the short term.