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目的为了解尖锐湿疣患者部分细胞因子及血清可溶性粘附分子水平。方法采用ELISA法检测了46例尖锐湿疣患者血清中白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)可溶性细胞间粘附分子-1(sICAM-1)和可溶性E-选择素(sE-selectin)水平。结果患者血清IL-6明显低于正常对照组(P<0·01),TNF-α、sE-selectin明显高于正常对照组(P<0·01),sICAM-I差异无显著意义。结论尖锐湿疣患者存在免疫缺陷和血清粘附分子水平的异常,可能与本病的复发有一定关系。
Objective To understand some patients with genital warts cytokines and serum soluble adhesion molecule levels. Methods Serum levels of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) levels. Results Serum IL-6 levels in patients were significantly lower than those in the normal control group (P <0.01). The levels of TNF-α and sE-selectin were significantly higher than those in the normal control group (P <0.01). There was no significant difference in sICAM-I between the two groups. Conclusions The patients with condyloma acuminatum have abnormal immunodeficiency and serum adhesion molecule level, which may be related to the recurrence of this disease.