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目的：了解低分子肝素（LMWHs）在治疗急性脑梗塞的疗效、抗凝纤溶功能及对血脂的作用。方法：102例急性脑梗塞病人随机分组，对照组42例；治疗I组15例，用LMWHs0．4ml（4100IAXaIU）皮下注射，每天1次，连续10天；治疗11组45例，用LMWHs0．4ml皮下注射，每天2次，连续10天。结果：Ⅱ组治疗后，纤维蛋白原（Fg）降低（－0．691．97，P＜0．001），凝血酶原时间（PT）延长（2．858．90，P＜0．001），血小板粘附率降低（－3．91520．54，P＜0．001），而对血脂无影响（P＞0．05），临床疗效明显（u＝2．17，P＜0．05）；I组对上述各项指标均无改善（P＞0．05）。结论：LMWHs具有抗凝溶栓作用，较大剂量，对治疗脑梗塞疗效较好。
Objective: To understand the therapeutic effect of low molecular weight heparin (LMWHs) on acute cerebral infarction, the anticoagulation and fibrinolytic function and its effect on blood lipids. Methods: A total of 102 patients with acute cerebral infarction were randomly divided into control group (n = 42), treatment group I (n = 15) and subcutaneous injection with LMWHs 0.4ml (4100IAXaIU) once daily for 10 days. Subcutaneous injection, 2 times a day for 10 days. Results: After treatment, the fibrinogen (Fg) decreased (P <0.001) and the prothrombin time (PT) increased in group Ⅱ (2.858.90, P <0.001) , Platelet adhesion rate decreased (-3.91520.54, P <0.001), but had no effect on blood lipids (P> 0.05). The clinical effect was obvious (u = 2.17, ; Group I did not improve the above indicators (P> 0.05). Conclusion: LMWHs have the anticoagulant and thrombolytic effect, and the higher dose is better for the treatment of cerebral infarction.