目的 :观察高频振荡通气 (HFO)联合低浓度一氧化氮 (NO)吸入对急性缺氧大鼠肺动脉高压的治疗作用。方法 :在 HFO下 ,经气管插管给大鼠 12 %氧 30分钟制成急性缺氧肺动脉高压模型 ,行肺泡再充气 ,吸入低浓度 NO(10、5、2 mm ol/ L )对模型动物进行治疗 ,测定血流动力学参数和血气值。结果 :2～ 10 m mol/ L NO吸入均可逆转急性缺氧大鼠肺动脉压 (PAP) ,收缩压 (s PAP)从 4.44～ 4.5 3 k Pa(1k Pa=7.5 m m Hg)降至 3.38～ 3.48k Pa;平均压 (m PAP)从 2 .5 8～ 2 .87k Pa降至 2 .0 0～ 2 .18k Pa;舒张压 (d PAP)从 2 .2 0～ 2 .70 k Pa降至1.6 7～ 1.82 k Pa。NO吸入前后体循环压和心率的变化无显著性差异 (P均 >0 .0 5 )。Pa O2 、Pa CO2 、p H和肺内动静脉分流 (Qs/ Qt)均无显著性差异 (P均 >0 .0 5 )。结论 :HFO联合低浓度 NO(2 mmol/ L)吸入对大鼠急性缺氧性肺动脉高压有明显疗效 ;2～ 10 mm ol/ L NO吸入对急性缺氧大鼠肺动脉高压的降压效应与 NO的浓度无明显剂量依赖性 Objective: To observe the therapeutic effect of high frequency oscillatory ventilation (HFO) combined with low concentration nitric oxide (NO) inhalation on pulmonary hypertension in acute hypoxic rats. Methods: Acute hypoxic pulmonary hypertension model was induced by 12% oxygen in rats under endotracheal intubation with HFO. Alveolar re-inflating was performed with low concentration of NO (10,5,2 mm ol / L) Treatment, determination of hemodynamic parameters and blood gas values. RESULTS: Pulmonary arterial pressure (PAP) of rats with acute hypoxia could be reversed by 2 ~ 10 m mol / L NO inhalation, and the s PAP decreased from 4.44 ~ 4.53 kPa (1k Pa = 7.5 mm Hg) to 3.38 ~ 3.48 kPa; m PAP decreased from 2.58 ~ 2.87 kPa to 2.00 ~ 2.18 kPa; diastolic blood pressure (d PAP) decreased from 2.20 ~ 2.70 kPa To 1.6 7 ~ 1.82 k Pa. There was no significant difference in the changes of body pressure and heart rate before and after NO inhalation (P> 0.05). Pa O2, Pa CO2, p H and pulmonary arteriovenous shunt (Qs / Qt) showed no significant difference (all P> 0.05). CONCLUSION: HFO combined with low concentration of NO (2 mmol / L) inhalation has a significant effect on acute hypoxic pulmonary hypertension in rats. The hypotensive effect of 2 ~ 10 mmol / L NO inhalation on pulmonary hypertension in acute hypoxic rats is associated with NO The concentration of no significant dose-dependent