【摘 要】
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Developing antibiotics-independent antibacterial agents is of great importance since antibiotic therapy faces great challenges from drug resistance.Graphene oxi
【机 构】
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State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China
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Developing antibiotics-independent antibacterial agents is of great importance since antibiotic therapy faces great challenges from drug resistance.Graphene oxide(GO)is a promising agent due to its natural antibacterial mechanisms,such as sharp edge-mediated cutting effect.However,the antibacterial activity of GO is limited by its negative charge and low photothermal effect.Herein,the amino-functionalized GO nanosheets(AGO)with unique three-in-one properties were synthesized.Three essential properties(positive charge,strong photothermal effect,and natural cutting effect)were integrated into AGO.The positive charge(30 mV)rendered AGO a strong interaction force with model pathogen Streptococcus mutans(330 nN).The natural cutting effect of 100 μg·mL-1 AGO caused 27％loss of bacterial viability after incubation for 30 min.Most importantly,upon the near-infrared irradiation for just 5 min,the three-in-one properties of AGO caused 98％viability loss.In conclusion,the short irradiation period and the tunable antibacterial activity confer the three-in-one AGO a great potential for clinical use.
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