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目的观察肺癌患者HP感染状况与胃泌素水平变化,探讨肺癌患者HP感染与胃泌素水平变化与肺癌发生的关系。方法采用14C呼气试验和放射免疫法对34例肺癌患者和42例支气管炎患者、29例支气管扩张患者进行HP感染检测和胃泌素水平测定。结果肺癌组幽门螺旋杆菌感染率与支气管炎患者、支气管扩张患者差异无统计学意义;肺癌组胃泌素水平明显高于支气管炎和支气管扩张组。结论部分肺癌患者存在HP感染和高胃泌素血症,但HP感染可能不是引起高胃泌素血症的主要因素。
Objective To observe the changes of HP infection and gastrin levels in patients with lung cancer and to explore the relationship between the changes of HP infection and the level of gastrin in patients with lung cancer and the occurrence of lung cancer. Methods 14C breath test and radioimmunoassay were used to detect HP infection and gastrin levels in 34 patients with lung cancer, 42 patients with bronchitis and 29 patients with bronchiectasis. Results The infection rate of Helicobacter pylori in lung cancer patients was not significantly different from that in patients with bronchitis and bronchiectasis. The levels of gastrin in lung cancer patients were significantly higher than those in patients with bronchitis and bronchiectasis. Conclusion Some patients with lung cancer have HP infection and hypergastrinemia, but HP infection may not be the main cause of hypergastrinemia.