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目的:探究阿昔洛韦对小儿传染性单核细胞增多症CD4+、CD8+的影响。方法:选取我院收治的小儿传染性单核细胞增多症的患者64例,随机分为两组。实验组予阿昔洛韦静脉滴注,对照组予利巴韦林静脉滴注。对比两组的临床疗效及CD4+、CD8+和CD4+/CD8+比值的变化情况。结果:1治疗后两组患儿临床疗效,实验组较对照组显著改善,差异有统计学意义(P<0.05)。2治疗后两组患儿退热时间、淋巴结消退时间、异型淋巴细胞消失时间以及住院时间等比较,实验组明显较对照组短,差异有统计学意义(P<0.05)。3治疗前,两组患者CD4+、CD8+以及CD4+/CD8+比值无统计学差异(P>0.05);治疗后,患者CD4+及CD4+/CD8+比值呈现先升高再降低的趋势,CD8+则呈现下降趋势,与对照组比较,实验组治疗3天,10天及1个月CD4+以及CD8+下降明显,差异具有统计学意义(P<0.05);CD4+/CD8+比值则较对照组升高(P<0.05)。结论:采用阿昔洛韦能够更好的改善患者临床症状,影响CD4+、CD8+的变化,使紊乱的免疫系统较快的恢复。
Objective: To investigate the effect of acyclovir on CD4 +, CD8 + in children with infectious mononucleosis. Methods: Sixty-four cases of pediatric infectious mononucleosis admitted to our hospital were randomly divided into two groups. The experimental group received acyclovir intravenously and the control group received ribavirin intravenously. The clinical efficacy and the ratio of CD4 +, CD8 + and CD4 + / CD8 + were compared between the two groups. Results: 1 The clinical curative effect of two groups of children after treatment was significantly improved in the experimental group compared with the control group, the difference was statistically significant (P <0.05). After treatment, the two groups of children with antipyretic time, lymph node subsidence time, atypical lymphocyte disappearance time and hospital stay, the experimental group was significantly shorter than the control group, the difference was statistically significant (P <0.05). Before treatment, the ratio of CD4 +, CD8 + and CD4 + / CD8 + was not significantly different between the two groups (P> 0.05). After treatment, the ratio of CD4 + and CD4 + / CD8 increased first and then decreased, while CD8 + Compared with control group, CD4 + and CD8 + in experimental group decreased significantly at 3 days, 10 days and 1 month (P <0.05), and CD4 + / CD8 + ratio increased (P <0.05) compared with control group. Conclusion: The use of acyclovir can better improve the clinical symptoms of patients, affect the changes of CD4 + and CD8 +, and make the disrupted immune system recover quickly.