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目的探讨紫杉醇、奈达铂同步后程加速超分割放疗联合体外高频热疗对局部晚期食管癌的影响。方法选取2011年8月~2012年7月承德市肿瘤医院收治的局部晚期食管癌患者144例,采用随机数字表法将其分为对照组(72例)与联合组(72例)。对照组患者应用紫杉醇、奈达铂同步后程加速超分割放疗干预,联合组患者在对照组放疗基础上联合体外高频热疗,对比两组患者治疗效果及生存率情况,观察两组患者毒副作用发生情况。结果联合组患者治疗总有效率(86.11%)明显高于对照组(62.50%),差异有统计学意义(P<0.05);两组患者治疗期间均存在毒副作用,两组毒副作用发生率差异无统计学意义(P>0.05);联合组患者1、2、3、4年生存率(70.83%、55.56%、45.83%、38.89%)明显高于对照组(55.56%、40.27%、29.17%、22.22%),差异有统计学意义(P<0.05)。结论局部晚期食管癌患者应用紫杉醇、奈达铂同步后程加速超分割放疗联合体外高频热疗治疗的效果较好,且生存率高,存在一定推广价值。
Objective To investigate the effect of paclitaxel, nedaplatin synchronous late-course hyperfractionated radiotherapy and external high frequency hyperthermia on locally advanced esophageal cancer. Methods 144 patients with locally advanced esophageal cancer admitted to Chengde Cancer Hospital from August 2011 to July 2012 were randomly divided into control group (72 cases) and combined group (72 cases). Patients in the control group were treated with paclitaxel and nedaplatin, and the latter was accelerated by hyperfraction radiotherapy. The patients in the combined group were treated with radiofrequency ablation combined with external high frequency hyperthermia in the control group. The therapeutic effect and survival rate were compared between the two groups. Side effects occur. Results The total effective rate (86.11%) in the combined group was significantly higher than that in the control group (62.50%), the difference was statistically significant (P <0.05); both groups had toxic side effects during treatment, 1, 2, 3, 4 years survival rate (70.83%, 55.56%, 45.83%, 38.89%) in the combined group was significantly higher than that in the control group (55.56%, 40.27%, 29.17% , 22.22%), the difference was statistically significant (P <0.05). Conclusion paclitaxel in patients with locally advanced esophageal cancer, nedaplatin synchronous late-accelerated hyperfractionated radiotherapy combined with high-frequency hyperthermia in vitro treatment is better, and the high survival rate, there is a certain promotional value.