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目的:评价盐酸阿罗洛尔治疗混合型心绞痛的疗效。方法:入选混合型心绞痛患者152例,其中59例进行平板运动试验.采用自身前后对照方法,予以盐酸阿罗洛尔5~10mg,bid,连续治疗4周。结果:治疗4周后,心绞痛发作次数、心绞痛发作持续时间、硝酸甘油消耗量、心率和血压均在治疗后明显下降(P<0.01)。59例运动试验结果显示,盐酸阿罗洛尔治疗4周后,患者运动总时间由(431.69±187.28)s延长到(561.75±204.56)s(P<0.01),运动时心绞痛出现时间由(277.07±168.68)s延长到(379.71±224.07)s(P<0.05),运动终止后ST段恢复正常所需时间由(350.00±178.52)s缩短为(136.38±72.13)s(P<0.01)。此外,最大ST压低值和ST压低导联数治疗前后也差异有统计学意义。结论:盐酸阿罗洛尔能明显减低混合型心绞痛患者心绞痛发作次数,减少心绞痛发作持续时间,并提高患者运动耐量。
Objective: To evaluate the efficacy of arotinolol in the treatment of mixed angina pectoris. Methods: A total of 152 patients with mixed angina were enrolled in this study, of which 59 patients underwent treadmill exercise test, and were treated with arotinolol 5 ~ 10 mg twice daily for 4 weeks. Results: After 4 weeks of treatment, the number of angina attacks, the duration of angina attacks, the consumption of nitroglycerin, heart rate and blood pressure decreased significantly after treatment (P <0.01). The results of exercise test in 59 cases showed that the total time of exercise increased from 431.69 ± 187.28 s to 561.75 ± 204.56 s (P <0.01) after 4 weeks of aroseol hydrochloride treatment, and the time of angina pectoris during exercise increased from (277.07 (378.71 ± 224.07) s to (379.71 ± 224.07) s and (136.88 ± 72.13) s to (136.38 ± 72.13) s, respectively (P <0.01) after the end of exercise. In addition, the maximum ST depression and ST low pressure lead before and after treatment were also statistically significant differences. Conclusion: Arotinolol can significantly reduce the number of angina attacks, reduce the duration of angina pectoris and improve the exercise tolerance of patients with mixed angina.