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动脉粥样硬化(AS)是心脑血管疾病的重要病理基础。中药抗AS的基础研究和临床试验正随着现代医学的发展而不断加深。本文就近年来这方面的研究进展综述如下。1 调脂作用 血脂异常——低密度脂蛋白胆固醇(LDL-C)增高和高密度脂蛋白胆固醇(HDL-C)降低是冠心病的主要危险因素,在AS的发生中占有十分重要的地位。许多基础试验均证实抗AS的中药都具有调脂作用。何首乌和何首乌藤及其提取物、山楂及其提取物、川芎、酸枣果肉均能降低高血脂动物的血浆TC、TG、β-脂蛋白,也能降低主动脉中的Ch和肝脏TG,使实验性AS兔的动脉内膜斑块形成及脂质蓄积明显减
Atherosclerosis (AS) is an important pathological basis of cardiovascular and cerebrovascular diseases. Basic research and clinical trials of traditional Chinese medicine anti-asthma are continuously deepening with the development of modern medicine. This article summarizes the research progress in this area in recent years as follows. 1 lipid regulation lipid abnormalities - low density lipoprotein cholesterol (LDL-C) increased and high-density lipoprotein cholesterol (HDL-C) reduction is the main risk factor for coronary heart disease, occupying an important position in the occurrence of AS. Many basic tests have confirmed that anti-AS herbs have lipid regulating effects. Polygonum multiflorum, Radix Polygoni multiflori and its extracts, hawthorn and its extracts, Chuanxiong and wild jujube flesh can all reduce plasma TC, TG, and β-lipoprotein in hyperlipidemia animals, and can also reduce Ch and liver TG in the aorta. Arterial Intimal Plaque Formation and Lipid Storage Significantly Decreased in AS Rabbits