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目的 :探讨血小板膜蛋白结构在高原肺心病动脉高压中的改变及致病作用机理 ;方法 :运用多克隆抗体 ,流式细胞计等技术对 5 8例高原肺心病患者进行血小板膜结合纤维蛋白原和血小板膜糖蛋白Ⅲα免疫荧光测定 ,并进行心脏超声检查 ;结果 :血小板膜结合纤维蛋白原 ,血小板膜糖蛋白 ,肺动脉压力和肺动脉阻力较正常对照组明显升高 (P<0 .0 1 ) ,结合纤维蛋白原和糖蛋白Ⅲα愈高 ,肺动脉压升高愈明显 ;结论 :血小板膜蛋白结构改变对高原肺心病肺动脉压形成有重要作用。
OBJECTIVE: To investigate the mechanism of platelet membrane protein structure alteration and pathogenic mechanism in plateau pulmonary heart disease (PAH). Methods: Fifty-eight patients with plateau pulmonary heart disease were treated with polyclonal antibody and flow cytometry to detect platelet membrane-bound fibrinogen And platelet glycoprotein Ⅲα immunofluorescence assay were performed. Cardiac echocardiography was performed. Results: Platelet membrane-bound fibrinogen, platelet membrane glycoprotein, pulmonary artery pressure and pulmonary artery resistance were significantly higher than those of the normal control group (P <0.01) , Combined with the higher fibrinogen and glycoprotein Ⅲ α, the more obvious pulmonary hypertension; Conclusion: platelet membrane protein structural changes of pulmonary hypertension pulmonary hypertension have an important role.