KAl(SO_4)_2·12H_2O catalyzed efficient synthesis of 3,4,6-trisubstituted 2-pyridone in water

来源 :Chinese Chemical Letters | 被引量 : 0次 | 上传用户:terzaghi
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An efficient green protocol for the preparation 3,4,6-trisubstituted 2-pyridone of employing a condensation reaction of cyanoacetamide and acetylacetone in the presence of KAl(SO_4)_2·12H_2O in water has been described.The present procedure offers advantage such as shorter reaction time,simple workup,and excellent yields. An efficient green protocol for the preparation 3,4,6-trisubstituted 2-pyridone of employing a condensation reaction of cyanoacetamide and acetylacetone in the presence of KAl (SO 4) _2 · 12H 2 O in water has been described. The present procedure offers advantage such as shorter reaction time, simple workup, and excellent yields.
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