患者男 ,2 9岁 ,结婚 5年。妻子妊娠 4次 ,在无任何诱因的情况下 ,前 3次于孕 50天～ 60天时发生自然流产 ,第 4次在妊娠 7+月时胎儿死于宫内。孕期均无病毒、细菌感染史。无服药、有害物质及Ｘ线接触史。夫妇非近亲婚配。患者表型、智力正常。精液检查也未见异常。妻子 2 5岁 Male patient, 29 years old, married for 5 years. Wife 4 times in pregnancy, without any incentive, the first 3 times in pregnancy 50 days to 60 days when spontaneous abortion occurs, the fourth in the 7th month of pregnancy when the fetus died of intrauterine. No virus during pregnancy, history of bacterial infection. No medication, harmful substances and history of X-ray exposure. Couples non-relatives marriage. Patient phenotype, mental normal. No abnormal semen examination. Wife 2 5 years old