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目的 :观察奥美拉唑 +阿莫西林 +甲硝唑和枸橼酸铋雷尼替丁 (复方制剂 ) +阿莫西林 +甲硝唑根除幽门螺旋杆菌 (Hp)的效果。 方法 :选择 2 0 0 2年 1月～ 2 0 0 2年 11月我院Hp检测阳性的胃炎、消化性溃疡 75例 ,随机分为两组。A组 :奥美拉唑 4 0mg ,1次 /晨 ,阿莫西林 1 0g ,2次 /天 ,甲硝唑 0 4 g ,2次 /天 ,共 7天 ;B组 :枸橼酸铋雷尼替丁 35 0mg ,2次 /天 ,阿莫西林 1 0 g ,2次 /天 ,甲硝唑 0 4 g ,2次 /天 ,共 7天。治疗结束 4周后复查14 C尿素呼气试验 ( 14 C UBT)为阴性 ,即为Hp根除。 结果 :A组HP根除率83 8% ,B组HP根除率 89 5 % ,HP根除率A组与B组差异不显著 (P >0 0 5 )。A组 2例 ,B组 1例出现不良反应 ,表现为恶心、食欲不振 ,均坚持全疗程。结论 :三联疗法是根除Hp的有效方案 ,适合临床推广应用。由于Hp的耐药性呈上升趋势 ,根除Hp时 ,最好选择含铋剂的三联方案。
Objective: To observe the effect of omeprazole + amoxicillin + metronidazole and ranitidine bismuth citrate (compound) + amoxicillin + metronidazole in the eradication of Helicobacter pylori (Hp). Methods: From January 2012 to November 2002, 75 cases of gastritis and peptic ulcer were detected in our hospital and were randomly divided into two groups. Group A: omeprazole 4 0mg, 1 time / morning, amoxicillin 10g, 2 times / day, metronidazole 0 4 g, 2 times / day for 7 days; B group: bismuth citrate bismuth Nilotin 35 0mg, 2 times / day, amoxicillin 10g, 2 times / day, metronidazole 0 4 g, 2 times / day for a total of 7 days. Four weeks after the end of treatment, the 14 C urea breath test (14 C UBT) was negative, ie Hp eradication. Results: The eradication rate of HP in group A was 83.8%, that of HP in group B was 89.5%, and the eradication rate of HP was no significant difference between group A and group B (P> 0.05). A group of 2 cases, B group 1 case of adverse reactions, manifested as nausea, loss of appetite, insist on the whole course of treatment. Conclusion: triple therapy is an effective eradication of Hp program, suitable for clinical application. As the drug resistance of Hp is on the rise, it is best to choose the triple solution containing bismuth for eradicating Hp.