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目的探讨氯氮平、利培酮对心电图QT离散度(QTd)的影响及QTd对猝死的预防价值。方法取氯氮平、利培酮两研究组和正常对照组各200例,研究组分别于治疗前、治疗后4周测心电图QT间期各一次。结果研究组治疗前的QTd及校正后的QTcd与正常对照组比较均无显著性差异(P>0.05);氯氮平组治疗前、后QTd、QTcd变化的自身比较,均有显著性差异(P<0.01);利培酮组治疗前、后QTd、QTcd变化的自身比较,均无显著性差异(P>0.05)。结论氯氮平对心电图QTd、QTcd有明显的影响,利培酮对心电图QTd、QTcd无明显影响。
Objective To investigate the influence of clozapine and risperidone on the QTd of electrocardiogram (QTd) and the value of QTd in preventing sudden death. Methods Clozapine, risperidone two study groups and normal control group of 200 cases, the study group were treated before treatment, 4 weeks after treatment, the QT interval ECG. Results There was no significant difference in QTd before treatment and QTcd after correction between the two groups (P> 0.05). QTd and QTcd changes before and after treatment in the clozapine groups were significantly different P <0.01). There was no significant difference in the changes of QTd and QTcd before and after treatment in risperidone group (P> 0.05). Conclusions Clozapine has obvious effect on QTd and QTcd of electrocardiogram. Risperidone has no obvious effect on QTd and QTcd of electrocardiogram.