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双丁酰ｃＡＭＰ是一种诱导分化剂，对体外培养的癌细胞具有一定诱导分化作用。本文着重观察了双丁酰ｃＡＭＰ对培养的人肺腺癌细胞膜上多种凝集素受体表达的影响，并将体外经双丁酰ｃＡＭＰ处理的癌细胞接种于裸鼠皮下，观察移植瘤自发性生长状况。结果表明，经双丁酰ｃＡＭＰ处理的人肺腺瘤细胞表面数种凝集素受体表达降低，同时伴有移植后成瘤潜伏期延长、侵袭能力下降。由于癌细胞膜结构和功能的改变与癌细胞的识别粘附及侵袭能力密切相关，这一结果提示双丁酰ｃＡＭＰ对癌细胞膜的影响可能是恢复癌细胞间粘附识别作用，降低其侵袭能力的机制之一。
Bis-butyryl cAMP is a differentiation-inducing agent that has a certain induction and differentiation effect on cancer cells cultured in vitro. This article focused on observing the effect of dibutyryl cAMP on the expression of multiple lectin receptors on cultured human lung adenocarcinoma cells, and inoculating bis-butyryl cAMP-treated cancer cells in nude mice subcutaneously to observe the spontaneousity of transplanted tumors. Growth Status. The results showed that the expression of several lectin receptors on the surface of human lung adenoma cells treated with dibutyryl cAMP was reduced, and the latency of tumor formation was prolonged and the invasive ability was decreased after transplantation. Since the changes in the structure and function of cancer cell membranes are closely related to the ability of cancer cells to recognize adhesion and invasion, this result suggests that the effect of dibutyryl cAMP on cancer cell membranes may be to restore the adhesion and recognition ability of cancer cells and reduce their invasiveness. One of the mechanisms.