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目的 探讨唾液酸化的路易斯寡糖-X (sLex)抗原在大肠癌及大肠癌肝转移病人中表达的临床意义。方法 应用LSAB法检测原发性大肠癌及大肠癌肝转移灶中sLex抗原的表达。结果 在原发性大肠癌中，sLex抗原染色阳性率为100%，其中高分化腺癌sLex抗原表达呈弱阳性，低分化腺癌sLex抗原表达呈阳性或强阳性；在大肠癌肝转移灶中，sLex抗原染色阳性率为100%，肝转移灶中sLex抗原的表达强于原发灶中sLex抗原的表达。结论 sLex抗原的检测可作为大肠癌肝转移及预后指标，对判断大肠癌肝转移及估价预后有重要意义。
Objective To investigate the clinical significance of the expression of sialyl Lewis oligosaccharide-X (sLex) antigen in patients with colorectal cancer and colorectal liver metastases. Methods The LSAB method was used to detect the expression of sLex antigen in primary colorectal cancer and liver metastases. Results In primary colorectal cancer, the positive rate of sLex antigen staining was 100%, of which sLex antigen expression was poorly positive in well-differentiated adenocarcinoma, and sLex antigen expression was positive or strongly positive in poorly differentiated adenocarcinoma; in liver metastases of colorectal cancer. The positive rate of sLex staining was 100%. The expression of sLex antigen in liver metastases was stronger than that of sLex antigen in primary lesions. Conclusions The detection of sLex antigen can be used as an indicator of hepatic metastasis and prognosis of colorectal cancer, which is of great significance in judging the liver metastasis of colorectal cancer and in evaluating the prognosis.