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目的 为了解HIV感染者免疫系统中CD_4~+、CD_8~+T淋巴细胞的变化与AIDS发展的关系.方法 对20名HIV感染者进行随访调查和CD_4~+、CD_8~+ T淋巴细胞检测.结果 95%的感染者CD_4~+、CD_8~+ T淋巴细胞数量明显低于正常值,CD_4~+/CD_8~+比值均<1.无症状HIV感染者与AIDS病人CD_4~+ T淋巴细胞(?)为458～299,CD_8~+ T淋巴细胞(?)为1090～550,两者(?)比较P<0.05和P<0.01.结论 分析认为CD_4~+、CD_8~+ T淋巴细胞的变化始终出现在AIDS的整个病程中,其变化的情况直接反应出进展为AIDS的速度.
Objective To investigate the relationship between CD_4 ~ +, CD_8 ~ + T lymphocytes and the development of AIDS in the immune system of HIV-infected patients.Methods 20 HIV-infected patients were followed up and CD_4 ~ + and CD_8 ~ + T lymphocytes were detected. Results The number of CD_4 ~ +, CD_8 ~ + T lymphocytes in 95% infected patients was significantly lower than the normal value, and the ratio of CD_4 ~ + / CD_8 ~ + was <1. Asymptomatic HIV infected patients and AIDS patients CD_4 ~ + T lymphocytes ?) Was 458-299, CD8 + T lymphocytes (?) Was 1090-550, P <0.05 and P <0.01 respectively.Conclusions The changes of CD_4 ~ + and CD_8 ~ + T lymphocytes Always appear in the entire course of AIDS, the changes in the situation directly reflects the rate of progress to AIDS.