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小鼠i.p.氟哌啶醇2mg/kg后,出现僵住症,东莨胆硷可拮抗。i.p.20mg/kg后出现震颤、行动过缓、强直。上述表现是帕金森氏病的典型症状。实验结果表明,用氟哌啶醇制作帕金森氏病模型是简易可靠的。
Mouse i. p. Haloperidol 2mg / kg, the emergence of catalepsy, scopolamine can be antagonistic. Tremor occurs after i.p.20 mg / kg, and bradykinesia is slow. The above symptoms are typical symptoms of Parkinson’s disease. Experimental results show that the use of haloperidol Parkinson’s disease model is simple and reliable.