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The cerebral ischemia-reperfusion model was established using the suture occlusion method,and rats were intraperitoneally given 8 mL/kg Danhong injection once a day prior to mode establishment.Rat brain tissues were harvested at 6,24,48,72 hours after reperfusion Immunohistochemical staining showed that transforming growth factor-β1 expression increased while Golgi matrix protein GM130 expression decreased after cerebral ischemia-reperfusion Danhong injection was shown to significantly up-regulate the expression of transforming growth factor-β1 and GM130,and expression levels peaked at 7 days after reperfusion.At 7 days after cerebral ischemia-reperfusion,Golgi morphology was damaged in untreated rats,while Golg morphology breakage was not observed after intervention with Danhong injection.These experimental findings indicate that Danhong injection can up-regulate the expression of transforming growth factor-β1 and GM130,and maintain Golgi stability,thus playing a neuroprotective role in rats after cerebral ischemia-reperfusion.
The cerebral ischemia-reperfusion model was established using the suture occlusion method, and rats were intraperitoneally given 8 mL / kg Danhong injection once a day prior to mode establishment. Rat brain tissues were harvested at 6, 24, 48, 72 hours after reperfusion Immunohistochemical staining showed that transforming growth factor-β1 expression increased while cerebral ischemia-reperfusion Danhong injection was shown as up-regulate the expression of transforming growth factor-β1 and GM130, and expression levels peaked at 7 days after reperfusion. At 7 days after cerebral ischemia-reperfusion, Golgi morphology was damaged in untreated rats, while Golg morphology breakage was not observed after intervention with Danhong injection. These experimental findings indicate that Danhong injection can up-regulate the expression of transforming growth factor- β1 and GM130, and maintain Golgi stability, thus playing a neuroprotective ro le in rats after cerebral ischemia-reperfusion.