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目的观察斑蝥酸钠维生素B6注射液联合奈达铂胸腔注入治疗恶性胸腔积液的疗效和不良反应。方法将73例肺癌并发恶性胸腔积液患者随机分为观察组(38例)和对照组(35例),观察组患者用一次性中心静脉引流专用导管胸腔置管闭式引流胸腔积液后,胸腔内注射斑蝥酸钠维生素B6注射液和奈达铂;对照组患者胸腔内仅注射奈达铂。观察组胸腔给药:斑蝥酸钠维生素B6注射液50 ml+生理盐水20 ml+奈达铂100 mg;对照组胸腔给药:奈达铂100 mg+生理盐水70 ml。结果观察组患者的临床总有效率和生活质量改善率均优于对照组(均P<0.05),两组患者不良反应差异无统计学意义(P>0.05)。结论胸腔灌注斑蝥酸钠维生素B6注射液联合奈达铂治疗恶性胸腔积液的疗效优于单用奈达铂,不良反应轻。
Objective To observe the curative effect and adverse reactions of sodium cantharidate vitamin B6 injection combined with nedaplatin injection in the treatment of malignant pleural effusion. Methods Seventy-three patients with malignant pleural effusion with lung cancer were randomly divided into the observation group (38 cases) and the control group (35 cases). The patients in the observation group were treated with closed drainage of special drainage tube for central venous drainage after closed catheterization. Intra-thoracic injection of sodium cantharidinate vitamin B6 injection and nedaplatin; control group patients with intra-thoracic injection of only nedaplatin. The observation group thoracic administration: cantharidin sodium vitamin B6 injection 50 ml + saline 20 ml + nedaplatin 100 mg; control group, intrapleural administration: nedaplatin 100 mg + saline 70 ml. Results The total clinical effective rate and quality of life improvement rate in the observation group were better than those in the control group (all P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusions Thoracic perfusion of sodium cantharidate vitamin B6 injection combined with nedaplatin in the treatment of malignant pleural effusion is superior to the single use of nedaplatin, with mild adverse reactions.