论文部分内容阅读
癌症研究最有希望的途径之一是发现癌基因并探讨其特性。作者综述这方面的观察结果,指出其可能的生物学意义,并为将来的工作指出方向。某些癌基因的发现和性质:人们最初认为癌基因是能在体内诱导肿瘤,体外转化细胞的RNA肿瘤病毒基因组的一部分。但进一步的工作提示病毒癌基因实际上是经转导的细胞基因,可用v-onc表示转导的病毒癌基因,c-onc表示v-onc的细胞祖先,并命名为细胞癌基因。 Src是Rous肉瘤病毒基因的一个转化区段,不是病毒自身复制的必需的成份。癌基因在癌变中的作用:已经发现,启动和维持转化表型只需src产物,缺乏酪氨酸激酶活性的src基
One of the most promising approaches to cancer research is the discovery of oncogenes and their characterization. The author reviews the observations in this area, points out its possible biological significance, and points out the direction for future work. The discovery and nature of certain oncogenes: It was originally thought that oncogenes were part of the RNA oncovirus genome that could induce tumors in vivo and transform cells in vitro. However, further work suggests that the viral oncogene is actually a transduced cellular gene, that v-onc can be used to refer to the transduced viral oncogene, c-onc is the cell progenitor of v-onc, and it is named cell oncogene. Src is a transformation section of the Rous sarcoma virus gene and is not an essential component of viral replication itself. The role of oncogenes in carcinogenesis: It has been found that the src product is required for the initiation and maintenance of the transformed phenotype, and the src group lacks tyrosine kinase activity.