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目的 :观察新型血管紧张素 受体拮抗剂氯沙坦钾的降压疗效。方法 :42例原发性高血压 (EH)患者每天服用氯沙坦钾 50 mg,疗程 4～ 8周 ,均以 2 4 h动态血压作为监测及评价方法。结果 :2 4 h收缩压和舒张压均明显下降 (P <0 .0 1 ) ,收缩压谷峰比 =70 % ,舒张压谷峰比 =52 % ,对夜间血压不产生过度降压作用 ,且对血糖、血脂、血尿酸无不良影响 ,副反应发生率低。结论 :每日服用 50 mg氯沙坦钾对 EH有 2 4 h平稳降压作用
Objective: To observe the antihypertensive effects of losartan potassium, a new type of angiotensin Ⅱ receptor antagonist. Methods: 42 patients with essential hypertension (EH) were given losartan potassium 50 mg every day for 4 to 8 weeks, and 24 hours ambulatory blood pressure was used as a monitoring and evaluation method. Results: Systolic and diastolic blood pressures were significantly decreased at 24 hours (P <0.01). The systolic-trough peak-to-peak ratio was 70% and the diastolic peak-trough ratio was 52% And blood sugar, blood lipids, uric acid no adverse effects, the incidence of side effects. CONCLUSION: 50 mg losartan potassium exerts a steady antihypertensive effect on EH for 24 h