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目的:据报道HIV-1感染的患者,尤其在晚期患者中,脑白质的改变是主要的神经病理特征。本研究对照相应年龄的健康志愿者的正常脑白质图谱,对不同临床分期的HIV患者进行全脑的各向异性(FA)及表观扩散系数(ADC)值的统计学分析。方法:经书面同意后,征集22位健康志愿者(年龄40．8± 6．3岁)及29位HIV患者(年龄41．2±7．4岁)。根据临床标准,将HIV患者分为如下3期:HIV伴随痴呆(HAD)、轻度认知运动功能障碍(MCMD)及亚临床轻度认知运动功能障碍。使用单次激发平面回波扩散张量成像(EPI-DTI)序列及施加6 个方向的扩散梯度得到DTI图像。使用Siemens Allegra 3T MR系统。利用Tukey’s检验,对正常组及不同分期的患者组
PURPOSE: It has been reported that HIV-1-infected patients, especially in patients with advanced stage, are major neuropathological features of changes in the white matter. In this study, we compared the normal white matter atlas of healthy volunteers of corresponding age with statistical analysis of whole brain anisotropy (FA) and apparent diffusion coefficient (ADC) values of HIV patients with different clinical stages. METHODS: Twenty-two healthy volunteers (aged 40.8 ± 6.3 years) and 29 HIV patients (aged 41.2 ± 7.4 years) were recruited with written consent. According to clinical criteria, HIV patients were divided into three phases: HIV associated dementia (HAD), mild cognitive impairment (MCMD) and subclinical mild cognitive dyskinesia. DTI images were obtained using a single-shot planar echocardiographic diffusion tensor imaging (EPI-DTI) sequence and applying a diffusion gradient in six directions. Use Siemens Allegra 3T MR system. Tukey’s test was used for the normal group and patient groups with different stages