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[目的]比较小牛脾提取物注射液联合化疗与单纯化疗对晚期食管癌的疗效、毒副反应及免疫功能的影响。[方法]78例晚期食管癌患者随机分为两组:单纯化疗组(对照组)采用紫杉醇加顺铂方案化疗;治疗组化疗方案同对照组,并同时给予小牛脾提取物注射液静脉滴注。均3周为1个周期,至少治疗2个周期。[结果]治疗组与对照组的中位生存时间及1年生存率无差异。治疗组生活质量KPS评分高于对照组,差异有显著性(P<0.05);治疗组血液毒副反应、胃肠道反应、对免疫功能的影响均明显低于对照组(P<0.05)。[结论]小牛脾提取物注射液联合化疗治疗晚期食管癌能提高疗效,降低化疗对患者免疫功能的影响,减轻毒副反应,改善患者的生活质量。
[Objective] To compare the curative effect, side effects and immune function of calf spleen extract injection combined with chemotherapy and chemotherapy alone on advanced esophageal cancer. [Methods] 78 patients with advanced esophageal cancer were randomly divided into two groups: chemotherapy alone group (control group) with paclitaxel and cisplatin chemotherapy; treatment group chemotherapy with the control group, while given calf spleen extract injection intravenous drip Note. All three weeks for a period of at least 2 cycles of treatment. [Results] There was no difference in the median survival time and 1-year survival rate between the treatment group and the control group. The KPS score of the quality of life in the treatment group was higher than that in the control group (P <0.05). The blood toxicity, gastrointestinal reaction and immune function in the treatment group were significantly lower than those in the control group (P <0.05). [Conclusion] Ma spleen extract injection combined with chemotherapy for advanced esophageal cancer can improve the curative effect, reduce the influence of chemotherapy on immune function, reduce the side effects and improve the quality of life of patients.