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目的了解单硝酸异山梨酯联合川芎嗪注射液治疗慢性肺源性心脏病心力衰竭的疗效。方法选择62例慢性肺源性心脏病功能失代偿期的患者,随机分为治疗组32例,对照组例31例。对照组采用抗感染、强心利尿等治疗,对照组在此基础上加用单硝酸异山梨酯联合川芎嗪注射液,观察比较两组的疗效。结果临床疗效治疗组优于对照组(P<0.05),治疗组血液流变学指标变化、C-反应蛋白变化及血流动力学变化较对照组明显降低(P<0.05)。结论单硝酸异山梨酯联合川芎嗪注射液治疗慢性肺源性心脏病心力衰竭疗效显著。
Objective To investigate the efficacy of isosorbide mononitrate and ligustrazine injection in the treatment of heart failure with chronic cor pulmonale. Methods Sixty-two patients with decompensated chronic cor pulmonale were randomly divided into treatment group (n = 32) and control group (n = 31). The control group was treated with anti-infective and cardiac-diuretic treatment. In the control group, isosorbide mononitrate plus ligustrazine mononitrate injection was added to the control group. The curative effect of the two groups was observed and compared. Results The clinical efficacy of the treatment group was better than that of the control group (P <0.05). The changes of hemorheology index, C-reactive protein and hemodynamics in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Isosorbide mononitrate combined with ligustrazine injection in the treatment of chronic cor pulmonale heart failure has a significant effect.