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目的观察舍曲林治疗老年脑卒中后抑郁状态的临床效果。方法选择老年脑卒中后抑郁状态患者78例,采用随机数字法将其分为2组,每组39例,2组均给予常规治疗,观察组给予舍曲林治疗,对照组给予阿米替林治疗,比较2组治疗前后汉密顿抑郁量表评分(HRSD)及疗效。结果治疗前2组HRSD评分比较差异无统计学意义(P>0.05),治疗后,2组HRSD评分均显著下降,且观察组低于对照组(P<0.05);观察组总有效率为94.87%高于对照组的74.36%,差异有统计学意义(P<0.05)。结论舍曲林治疗老年脑卒中后抑郁状态疗效显著,可显著改善患者的抑郁状态,值得临床推广。
Objective To observe the clinical effect of sertraline on senile post-stroke depression. Methods 78 elderly patients with post-stroke depression were selected and randomly divided into two groups, 39 cases in each group. The two groups were given conventional treatment. The observation group was treated with sertraline. The control group was treated with amitriptyline Treatment, the two groups before and after treatment, the Hamilton Depression Scale score (HRSD) and efficacy. Results There was no significant difference in HRSD scores between the two groups before treatment (P> 0.05). After treatment, the HRSD scores of two groups were significantly decreased, and the observation group was lower than the control group (P <0.05). The total effective rate of the observation group was 94.87 % Higher than the control group of 74.36%, the difference was statistically significant (P <0.05). Conclusion Sertraline treatment of depression in elderly patients with significant effect, can significantly improve the patient’s depression, is worthy of clinical promotion.