羊膜穿刺术是现在非常有用的方法,主要用于中期妊娠诊断胎儿染色体异常、神经管缺陷、先天性代谢异常和X连锁病。就流产、出血、羊膜炎和母体损伤的发病率很低来看,羊膜穿刺术极安全。但也有刺伤胎儿的危险,有报道晚期妊娠行羊膜穿刺造成胎儿损伤的病例,而关于孕中期施行此术刺伤胎儿的并发症几乎无知。本文介绍孕中期行羊膜穿刺术时胎儿损伤的发生率和严重性,并指出了预防因素。 Amniocentesis is now a very useful method, mainly for the diagnosis of fetal chromosomal abnormalities in the second trimester, neural tube defects, congenital metabolic abnormalities and X-linked disease. In terms of the low incidence of miscarriage, bleeding, amniotic inflammation and maternal injury, amniocentesis is extremely safe. However, there is also a risk of stabbing the fetus. There are reports of fetal injury caused by amniocentesis in late pregnancy, and there is almost no complication about the fetus impacted during the second trimester. This article describes the incidence and severity of fetal injury during the second trimester of amniocentesis and points out the prophylactic factors.