论文部分内容阅读
目的了解四川省凉山州首次接受抗病毒治疗(ART)的艾滋病(AIDS)病人,因AIDS死亡的情况及其影响因素。方法对2005-2012年中国艾滋病ART信息管理系统中的5525例凉山州艾滋病病人的基本情况、死亡时间、治疗情况、CD+4T淋巴细胞(简称CD4细胞)计数检测结果等数据资料进行分析。结果共死亡430例,其中287例(66.7%)死于AIDS相关疾病。病人接受治疗时的平均年龄为(34.5±9.0)岁,男性占86.4%(248/287),经静脉吸毒感染占76.0%(218/287),从确认HIV抗体阳性到接受ART的时间平均为(21.0±19.1)个月,9.6%(26/271)的病例治疗前最近一年患有肺结核。按照世界卫生组织临床分期,50.4%(140/278)的病死病例在治疗开始时为临床I期;开始治疗时CD4细胞计数检测平均为(219.9±130.1)个/mm3,88.9%(240/270)在350个/mm3。34.1%(98/287)的病例开始治疗前3个月出现AIDS相关疾病/症状;平均时间为(12.7±10.6)个月。52.3%(150/287)是在治疗开始后的12个月内病死。不同性别、感染途径、临床分期、首次CD4细胞计数检测结果、治疗前最近一年是否患有肺结核的AIDS病人,其病死率的差异有统计学意义。结论因AIDS相关疾病死亡是凉山州接受ART病人死亡的主要原因;AIDS病人应定期进行随访和CD4细胞检测,及早接受ART。
Objective To understand the AIDS deaths and its influencing factors among the first AIDS patients receiving ART in Liangshan Prefecture, Sichuan Province. Methods The data of 5525 AIDS patients in Liangshan Prefecture from 2005 to 2012 were analyzed. The data of death, treatment, count of CD + 4T lymphocytes (CD4 cells count) were analyzed. Results A total of 430 deaths were observed, of which 287 (66.7%) died of AIDS-related diseases. The average age of patients receiving treatment was (34.5 ± 9.0) years, 86.4% (248/287) in men and 76.0% (218/287) in intravenous drug abuse. The average time from confirming HIV antibody positive to receiving ART was (21.0 ± 19.1) months, and 9.6% (26/271) had tuberculosis in the most recent year before treatment. According to the WHO clinical stage, 50.4% (140/278) of the dead cases were in clinical phase I at the beginning of treatment; meanwhile, CD4 cell count was (219.9 ± 130.1) / 88.9% (240/270 ) Developed AIDS-related diseases / symptoms 3 months prior to the start of treatment of 350 / mm3.34.1% (98/287) patients; the mean time was (12.7 ± 10.6) months. 52.3% (150/287) died of disease within 12 months after the start of treatment. According to different sex, route of infection, clinical stage, the result of the first CD4 count, the AIDS patients with tuberculosis in the most recent year before treatment, the difference in the case fatality rate was statistically significant. Conclusion The death of AIDS-related diseases is the main reason for the death of ART patients in Liangshan Prefecture. AIDS patients should be followed up regularly and CD4 cells detected, and ART should be accepted as early as possible.