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目的调查我国部分地区儿童b型流感嗜血杆菌(Haemophilus influenzae type b,Hib)荚膜多糖的组分多聚核糖基-核糖醇-磷酸盐(polyribosylribitol phosphate,PRP)的抗体(抗-PRP)水平。方法采用ELISA法对2007~2014年间来自我国广西壮族自治区、江苏省、河南省的13 799份2月龄~5岁健康儿童的血清标本进行抗-PRP自然抗体水平的检测。结果 2007~2014年间我国2月龄~5岁儿童抗-PRP自然抗体阳性率、抗体浓度达到长期保护水平的比例及抗体几何平均浓度(GMC)呈逐年升高的趋势,其中2~11月龄儿童的抗-PRP自然抗体阳性率较低;不同地区儿童抗-PRP自然抗体水平差异不大,且不同性别间抗体水平分布较均衡。结论我国2~11月龄儿童仍是Hib的易感人群,是需进行Hib结合疫苗预防接种的重点人群。
Objective To investigate the level of anti-PRP antibody against polyribosylribitol phosphate (PRP) in children with Haemophilus influenzae type b (Hib) capsular polysaccharide in some areas in China. . Methods Serum samples from 13 799 healthy children aged 2 months to 5 years from Guangxi Zhuang Autonomous Region, Jiangsu Province and Henan Province from 2007 to 2014 were tested for the level of anti-PRP antibody by ELISA. Results The positive rates of anti-PRP natural antibodies and the antibody long-term protection levels and the antibody mean geometric mean concentrations (GMCs) of 2-to-5-year-old children in our country from 2007 to 2014 were increasing year by year. The positive rate of anti-PRP natural antibodies in children was low. The levels of anti-PRP natural antibodies in children in different areas were not significantly different, and the antibody levels among different sexes were more evenly distributed. Conclusions Our children aged 2 ~ 11 months are still Hib susceptible population, and are the key population to be vaccinated with Hib conjugate vaccine.