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目的 :观察速避凝对心肺复苏术后早期脑复苏的疗效。方法 :对心肺复苏成功的 32例脑复苏患者随机分为对照组 (常规治疗组 )和实验组 (加用速避凝治疗组 ) ,观察各组复苏前后临床综合神经评分、血液流变学及血浆超氧化物歧化酶 (SOD)和丙二醛含量 (MDA)的变化。结果 :治疗后第 5天与复苏即刻比较 ,实验组临床神经综合评分及血浆 SOD含量明显提高 (P<0 .0 5 ) ,血液粘度显著降低 (P<0 .0 5 ) ;而对照组上述指标变化不明显 (P>0 .0 5 )。治疗后第 5天 ,实验组的临床神经综合评分及血浆 SOD含量明显高于对照组 ,而血液粘度显著低于对照组 (P<0 .0 5 ) ;两组患者血浆 MDA含量均无明显变化。结论 :心肺复苏术后早期脑复苏患者用速避凝可提高临床神经综合评分 ,减少自由基的生成 ,降低血液粘度 ,最终改善脑复苏患者的预后
OBJECTIVE: To observe the effect of immediate contraception on early cerebral resuscitation after cardiopulmonary resuscitation. Methods: A total of 32 patients with cerebral resuscitation after cardiopulmonary resuscitation (CPR) were randomly divided into control group (conventional treatment group) and experimental group (plus accelerated contraceptive treatment group). The clinical neurological score, hemorheology, Changes of plasma superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Results: Compared with the resuscitation immediately after the fifth day of treatment, the clinical neurological score and plasma SOD in the experimental group were significantly increased (P <0.05) and the blood viscosity was significantly decreased (P <0.05) Indicators did not change significantly (P> 0.05). On the fifth day after treatment, the clinical neurological score and plasma SOD in the experimental group were significantly higher than those in the control group, while the blood viscosity was significantly lower than that in the control group (P <0.05). There was no significant difference in the plasma MDA levels between the two groups . CONCLUSIONS: CPR in patients with early cerebral resuscitation after cardiopulmonary resuscitation can improve clinical neurological score, reduce the generation of free radicals, decrease blood viscosity and ultimately improve the prognosis of patients with cerebral resuscitation