论文部分内容阅读
目的探讨自体组织替代治疗男性超长段尿道狭窄对勃起功能的影响。方法回顾性分析2003年1月—2007年1月间23例不同自体组织替代治疗患者的临床资料,并进行IIEF-5评分、QOL评分及最大尿流率的术前与术后随方观察。结果所有患者术后3月、6月随访时的QOL评分、最大尿流率较术前均有明显改善(P<0.01):而IIEF-5的平均评分无明显改变(P>0.05)。狭窄部位累及至后尿道时,患者勃起功能有减弱趋势(P<0.05),同期比较中术后3月、6月随访时狭窄部位累及至后尿道患者的IIEF-5平均值要显著低于单纯前尿道狭窄的患者(P<0.05)。狭窄累及后尿道患者多元线性回归分析中,年龄、受伤时间以及尿道狭窄段的长度与替代术后IIEF-5评分呈现多元线性相关。结论自体组织替代治疗男性超长段尿道狭窄对勃起功能影响不明显:狭窄段累及后尿道时则可能对患者勃起功能产生一定的影响。患者年龄、受伤时间对勃起功能起到协同影响作用。
Objective To investigate the effect of autologous tissue replacement therapy on erectile function in male long urethral stricture. Methods The clinical data of 23 patients with different autologous tissue replacement therapy from January 2003 to January 2007 were retrospectively analyzed. The preoperative and postoperative follow-up observations of IIEF-5, QOL and maximum uroflow were performed. Results The QOL score and maximal uroflow rate of all patients at 3 months and 6 months after operation were significantly improved compared with that before operation (P <0.01). The mean score of IIEF-5 had no significant change (P> 0.05). In the same period, mean IIEF-5 in patients with posterior urethra at 3 months and 6 months follow-up was significantly lower than that in simple urethra patients (P <0.05) Patients with anterior urethral stricture (P <0.05). In the multiple linear regression analysis of patients with narrow involvement of the urethra, age, duration of injury, and the length of the urethral stricture were multivariate linearly correlated with postoperative IIEF-5 scores. Conclusion There is no obvious effect on the erectile function in patients with long segment of urethral stricture surgically replaced by autologous tissue: the erectile function may be affected when the stenosis involves the posterior urethra. Patient age and duration of injury have a synergistic effect on erectile function.