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妊娠急性脂肪肝系在孕期末三个月出现急性多系统损害的疾病,脑、肾、胰、心等组织均有脂肪变性,以肝脏最严重。临床除迅速出现急性肝功能衰竭、黄疸、高氨血症及肝性脑病外,同时亦有胰腺炎、肾功能衰竭及弥漫性血管内凝血等,常死于肝外因素。病因及病理妊娠脂肪肝与Reye氏综合征同属于微囊泡性脂肪症,肝组织学颇为相似,但因发病的主要因素不同,仔细检查病理亦有差异。
Acute fatty liver of pregnancy in the first trimester of pregnancy acute multiple system damage, brain, kidney, pancreas, heart and other organizations have steatosis, the most serious liver. In addition to acute clinical acute liver failure, jaundice, hyperammonemia and hepatic encephalopathy, but also pancreatitis, renal failure and disseminated intravascular coagulation, often due to extrahepatic factors. Etiology and pathology Fatty liver pregnancy and Reye’s syndrome belong to the class of microvesicular fatty disease, liver histology is quite similar, but due to the incidence of different major factors, double check the pathology are also different.