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人类巨细胞病毒(CMV)是疱疹病毒的亚类,也称为β-疱疹病毒。其特征是具有高度种属特异性和复制缓慢。CMV分布非常广,其流行率在欧洲人群达50％。与其它疱疹病毒相似,CMV在原发性感染后,病毒在宿主体内可终生持续存在。虽然隐伏的细胞部分尚未完全确定,但是为临床提出一重要问题:任何隐伏部位的病毒再活化均可导致反复发作性活动性感染。现今的研究指出:CMV可以在造血前体细胞内隐伏感染,在这些细胞内一定激活条件的作用(同种反应、细胞因子等)均可诱发感染的再激活。这点可以说明从血清阳性供血者移植干细胞的病人获得感染有极
Human cytomegalovirus (CMV) is a subclass of the herpes virus, also known as β-herpes virus. It is characterized by a high species-specific and slow replication. The distribution of CMV is very wide, with a prevalence of 50% in Europe. Like other herpes viruses, CMV can persist throughout the life of a host after the primary infection. Although the hidden part of the cell has not yet been fully defined, it poses an important clinical problem: reactivation of any concealed part of the virus can lead to recurrent episodes of active infection. Current research indicates that CMV can infect latent infection in hematopoietic progenitor cells, and the activation of certain conditions (allomics, cytokines, etc.) in these cells can induce the reactivation of the infection. This shows that patients who have transplanted stem cells from seropositive donors have a very high level of infection