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醋柳总黄酮对动物在大剂量(400mg/kg)一次口服、连续3～7日小量用药(100～200mg/kg/d)或腹腔给药(400mg/kg)时均可增加心肌营养血流量,降低心肌耗氧量,提高动物耐缺氧的能力,对抗垂体后叶素所致的急性缺血性心肌损伤。此外,本品还能降低血清胆固醇,抑制血小板聚集,这些药理作用可能是本品临床上治疗冠心病有较好疗效的药理基础。醋柳总黄酮的毒性实验表明,本品无明显毒性,也没有致畸和致突变作用,是一种安全而有效的药物。
The total flavonoids of vinegar will increase the amount of myocardial nutrient when the animals are given orally at large dose (400mg/kg) or small doses (100-200mg/kg/d) for 3 to 7 days or intraperitoneal (400mg/kg). Flow, reduce myocardial oxygen consumption, improve the ability of animals to resist hypoxia, against pituitrin caused by acute ischemic myocardial injury. In addition, this product can also reduce serum cholesterol, inhibit platelet aggregation, these pharmacological effects may be the clinical pharmacological basis for the treatment of coronary heart disease has a good effect. The toxicity test of total flavonoids of vinegar will show that the product has no obvious toxicity and no teratogenic and mutagenic effects. It is a safe and effective drug.