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本文报导7例血中有狼疮抗凝因子(LA)的脑梗塞病人,其中6例是在145例青年脑梗塞的回顾性研究中证实的,另1例则是其他医院的病例。其中男性1例,女性6例.年龄18～42岁。4例患有系统性红斑性狼疮,另3例则仅有特发性的 LA.7例病人血小板计数是7.8万～12.5万,(作者的正常标准是大于15万)凝血酶元时间11.0～14.1秒(正常对照为12秒),部分凝血质时间 PTT 均有延长达43～115秒(正常为40秒)。5例做过颈动脉造影,其中1例正常1例虹吸部有阻塞,1例颈动脉有狭窄,另2例颈动脉分支有阻塞。经平均2年随访中,7例中有4例发作1次卒中,2例有卒中发作,另有1例则有多数性卒中发作。在讨论中作者提出,LA 是一种后天获得性的免疫球蛋白 IgG 或 IgM,这些免疫球蛋白有抑制凝血酶
Seven cases of cerebral infarction with lupus anticoagulant factor (LA) in the blood were reported in this paper, of which 6 were confirmed in a retrospective study of 145 young adults with cerebral infarction and 1 in other hospitals. Including 1 males and 6 females, aged 18 to 42 years old. 4 patients with systemic lupus erythematosus, the other three cases only idiopathic LA.7 patients with platelet count was 78000 ~ 125000, (the author’s normal standard is more than 150,000) thrombin time 11.0 ~ 14.1 seconds (normal control of 12 seconds), partial thromboplastin time PTT were extended for 43 to 115 seconds (normal 40 seconds). Carotid angiography was performed in 5 cases, of which 1 had a stenosis of the siphon part, 1 had a stenosis of the carotid artery, and 2 had a blockage of the carotid artery. After an average of 2 years of follow-up, 4 out of 7 patients had a stroke, 2 had a stroke, and another had a majority of strokes. In the discussion, the authors propose that LA is an acquired acquired immunoglobulin IgG or IgM that inhibits thrombin