China′s economy and transport infrastructure have both experienced rapid development since 1978, and especially since 1990. Today, China is the second-largest economic entity in terms of GDP and has the largest high-speed rail(HSR) network and the second-largest expressway network in the world. This paper explores the relationship between accessibility and economic growth in China from 1990 to 2010. In the study, the basic research units include 333 prefecture-level cities and four municipalities. We explore a bivariate analysis framework of accessibility and economic growth, and their increase rates, to examine this relationship using long-term panel data. The results indicate that, first, accessibility and economic growth show a significant positive relationship using both cross-section and panel data, while the increase rate in accessibility and GDP indicate no significant relationship using cross-section data and a poor significant relationship using panel data. Second, the distributions of local advantage are uneven. Cities with low local advantage with respect to accessibility and GDP are mainly located in China′s eastern coastal region or the provincial capitals, while those with low local advantage in terms of their increase rates are located in the western region. Third, as China′s economic growth and transport networks have evolved, the distribution of local advantage shows little change in terms of accessibility and GDP, but a greater change in terms of their increase rates, which is largely influenced by the distribution of expressway and HSR networks. China’s economy and transport infrastructure have both experienced rapid development since 1978, and especially since 1990. Today, China is the second-largest economic entity in terms of GDP and has the largest high-speed rail (HSR) network and the second- largest expressway network in the world. This paper explores the relationship between accessibility and economic growth in China from 1990 to 2010. In the study, the basic research units include 333 prefecture-level cities and four municipalities. We explore a bivariate analysis framework of accessibility and economic growth, and their increase rates, to examine this relationship using long-term panel data. The results indicate that, first, accessibility and economic growth show a significant positive relationship using both cross-section and panel data, while the increase rate in accessibility and GDP si no significant relationship using cross-section data and a poor significant relationship using panel data. Second, the distr Cities with low local advantage with respect to accessibility and GDP are mainly located in China’s eastern coastal region or the provincial capitals, while those with low local advantage in terms of their increase rates are located in the western Third, as China’s economic growth and transport networks have evolved, the distribution of local advantage shows little change in terms of accessibility and GDP, but a greater change in terms of their increase rates, which is largely influenced by the distribution of expressway and HSR networks.