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十字花科蔬菜在酸性条件下的水解产物吲哚-3-甲醇在体内可被代谢为包括其二聚体3,3’-二吲哚甲烷在内的多种代谢产物。离体实验、动物实验和部分临床试验研究表明吲哚-3-甲醇或3,3’-二吲哚甲烷可通过多种生物学和生物化学机制,如诱导Ⅰ相和Ⅱ相代谢酶类干扰包括雌激素在内的致癌物代谢过程、影响与DNA修复相关的蛋白质表达而发挥增强DNA修复作用、诱导G1期细胞周期阻滞和凋亡的发生及对数种核转录因子的调节等,从而发挥抗肿瘤作用或对肿瘤的化学预防效应。
Indole-3-methanol, a hydrolyzate of cruciferous vegetables under acidic conditions, can be metabolized in vivo to various metabolites including its dimeric 3,3’-dipindole methane. In vitro, animal experiments and some clinical trials show that indole-3-methanol or 3,3’-diindole methane through a variety of biological and biochemical mechanisms, such as induction of phase Ⅰ and phase Ⅱ metabolic enzymes interference Including estrogen, including the carcinogen metabolism process, affecting DNA repair protein expression and enhance the role of DNA repair, induction of G1 cell cycle arrest and apoptosis and the regulation of several nuclear transcription factors, and thus Exert anti-tumor effect or chemopreventive effect on tumor.