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为研究脂蛋白原接种阻断Ａｓ的免疫病理机理，将４２只新生乳兔随机分为对照组（Ⅰ）和２个实验组（Ⅱ、Ⅲ）。Ⅱ、Ⅲ组于生后１２ｈ内及第７、１５天分别向腹腔注射分离纯化的ＶＬＤＬ０．５ｍｇ／只、１．０ｍｇ／只。１８周开始喂高胆固醇饲科。第１７、３０、４０周检测总补体（ＴＣ），血清免疫复合物（ＣＩＣ），体外吞菌百分数（ＳＰ）和杀菌率（ＫＢＲ）。结果表明，１７周时Ⅱ、Ⅲ组ＴＣ明显高于Ⅰ组，３０周时ＴＣ仍明显高于Ⅰ组；ＣＩＣ显著低于Ⅰ组。４０周时Ⅱ、Ⅲ组ＳＰ，ＫＢＲ显著低于Ⅰ组。提示生命早期接种脂蛋白原能够阻断Ａｓ的免疫病理过程。
In order to study the immunopathogenesis mechanism of lipoprotein inoculation blocking As, 42 neonatal rabbits were randomly divided into control group (Ⅰ) and two experimental groups (Ⅱ, Ⅲ). Groups Ⅱ and Ⅲ were injected intraperitoneally with VLDL0.5mg / only and 1.0mg / only respectively within 12h and 7th and 15th days after birth. 18 weeks began to feed high cholesterol feed. The total complement (TC), serum immune complex (CIC), percentage of in vitro phagocytosis (SP) and bactericidal rate (KBR) were detected at the 17th, 30th and 40th week. The results showed that at 17 weeks, the TC in group Ⅱ and Ⅲ was significantly higher than that in group Ⅰ, and the TC at 30 weeks was still significantly higher than that in group Ⅰ; the CIC was significantly lower than that in group Ⅰ. At 40 weeks, the SP and KBR in group Ⅱ and Ⅲ were significantly lower than those in group Ⅰ. It suggested that early vaccination of lipoprotein can block the immunopathological process of As.