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应用双抗体夹心ＥＬＩＳＡ法、放射免疫测定法和间接免疫荧光测定法，同步检测了４８例ＨＦＲＳ患者血清ＩＬ６，β２ＭＧ，特异性ＩｇＭ和ＩｇＧ的动态变化。结果表明，ＨＦＲＳ患者血清ＩＬ６水平发热期已高于正常组（Ｐ＜００１），并达较高水平，少尿期达高峰，与临床病情的进展相一致；ＩＬ６、特异性ＩｇＭ和ＩｇＧ分别于病程的第６ｄ，第９ｄ及第１１ｄ达高峰，ＩＬ６与血清球蛋白呈明显的正相关，ＩＬ６与ＨＦＲＳ患者病程中特异性抗体的升高有明显关系；轻、中、重和危重型患者血清ＩＬ６与ＩｇＧ间呈正相关，且ＩＬ６随病情加重而升高。提示：ＩＬ６可能与体液免疫功能亢进所致免疫病理损伤有关，并根据ＩＬ６与血清β２ＭＧ，尿素氮（ＢＵＭ）和肌酐（Ｃｒ）均呈高度正相关，表明ＩＬ６参与了肾脏的免疫损伤。
Double antibody sandwich ELISA, radioimmunoassay and indirect immunofluorescence assay were used to detect the dynamic changes of serum IL6, β2MG, specific IgM and IgG in 48 patients with HFRS simultaneously. The results showed that HFRS patients with serum IL 6 level fever period has been higher than the normal group (P <0 01), and reached a high level, oliguria reached a peak, consistent with the progress of clinical conditions; IL 6, specific Sex IgM and IgG in the course of the course of the 6d, 9d and 11d reached a peak, IL 6 and serum globulin was positively correlated, IL 6 and HFRS patients with elevated duration of specific antibodies have a clear relationship; Light, moderate, severe and critically ill patients serum IL 6 and IgG was positively correlated, and IL 6 increased with the aggravation of the disease. Hint: IL 6 may be associated with immunopathological damage caused by hypersensitivity to humoral immunity, and according to IL 6 and serum β2 MG, BUN and Cr were highly correlated, indicating that IL 6 involved Kidney immune damage.