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胃损害被认为是攻击因子与防御因子平衡失调的结果。胃酸、胃蛋白酶和活性氧为攻击因子,而粘液分泌、血流增加、前列腺素(PG)和HCO_3为防御因子。外源性前列腺素E_2(PGE_2)对坏死因子诱导的胃损害具有保护作用,但机制尚不清楚。在给予关苍术(Atractylodes japonica,在日本作苍术使用)汤剂的大鼠血中发现的乙炔化合物(6E,12E)-十四二烯-8,10-二炔-1,3-二醇二乙酸酯(TDEYA),被证实能保护活性氧诱导的
Gastric lesions are thought to be the result of an imbalance of attack and defense factors. Gastric acid, pepsin and reactive oxygen species are the attacking factors, while mucus secretion, increased blood flow, prostaglandins (PG) and HCO_3 are defensive factors. Exogenous prostaglandin E 2 (PGE 2 ) has a protective effect on necrosis factor-induced gastric lesions, but the mechanism remains unclear. Acetylene compound (6E,12E)-tetradecadiene-8,10-diyne-1,3-diol dihydrate found in rat blood of Atractylodes japonica (used in Atractylodes lanceolata) Acetate (TDEYA), proved to protect reactive oxygen species