论文部分内容阅读
氟喹诺酮类药物已被用于治疗结核分枝杆菌感染,已知口服环丙氟哌酸(C)750mg可产生2.01mg/L的血清浓度和4.86mg/kg的支气管组织浓度,C对结核杆菌的最小抑菌浓度(MIC)为0.5～1mg/L,但此药在人体的效力仍报道很少,为了评价C的早期杀菌和灭菌活性,作者进行了两个随机前瞻性研究。患者年龄≥18岁、近期诊断为肺结核者,有肺结核的临床和X线表现,痰菌阳性,并排除下列条件:严重肝肾和心脏疾病、妊娠或哺乳期、以往有抗结核治疗史、对研究药物有副反应史、癫痫、同时应用茶碱治疗受严重呼吸道疾病。研究Ⅰ.10例患者随机服用异烟肼300mg/d或C750mg/d共7天,在研究的第0、1、2、3、5、7天收集晨痰,7天后继用含有利福平的多种药物短程治疗。研究
Fluoroquinolones have been used to treat Mycobacterium tuberculosis infection and it is known that oral administration of 750 mg of ciprofloxacin (C) produces a serum concentration of 2.01 mg / L and a bronchial tissue concentration of 4.86 mg / kg, The minimum inhibitory concentration (MIC) of 0.5 ~ 1mg / L, but the efficacy of this drug in the human body is still reported very little, in order to evaluate the C early sterilization and sterilization activity, the authors conducted two randomized prospective study. Patients aged> 18 years old, the recent diagnosis of pulmonary tuberculosis, tuberculosis clinical and X-ray findings, sputum positive, and exclude the following conditions: severe liver and kidney and heart disease, pregnancy or breast-feeding, the past history of anti-TB treatment, Research drugs have side effects, epilepsy, while theophylline treatment of severe respiratory diseases. Study I.10 Patients were randomized to isoniazid 300 mg / day or C 750 mg / day for 7 days. Morning sputum was collected on study days 0, 1, 2, 3, 5 and 7. After 7 days, A variety of drug short-course treatment. the study