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前言尿毒症被称为“天然的免疫抑制模型”。多年来,人们研究了尿毒症时的免疫反应变化,探求它的机理。实验表明:尿毒症时,细胞免疫反应明显受到抑制,依赖于辅助性T细胞的体液免疫反应有较明显的损害,与T细胞和B细胞相互作用关系不大的体液免疫反应正常或仅稍减弱。动物模型的研究进一步表明:尿毒症时的免疫抑制现象与抑制性细胞活性增高及血清中存在免疫抑制因子有关。此外,也与粒细胞功能障碍、透析疗法、营养缺乏(特别是蛋白质、锌、维生素B_6、磷缺乏)、
Introduction Uremia is called “natural immunosuppressive model.” Over the years, people have studied the changes of immune response in uremia and explored its mechanism. Experiments show that: uremia, the cellular immune response was significantly inhibited, dependent on the T-cell humoral immune response more obvious damage, and T cells and B cells interaction of humoral immune response is not normal or only slightly weakened . Studies in animal models further indicate that the phenomenon of immunosuppression during uremia is associated with increased inhibitory activity and presence of immunosuppressive agents in serum. In addition, it is also associated with granulocyte dysfunction, dialysis therapy, nutritional deficiencies (particularly protein, zinc, vitamin B_6, phosphorus deficiency),