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α_1微球蛋白(α_1-MG)是一种分子量为3300道尔顿的糖蛋白,主要在肝脏和淋巴细胞中产生,并广泛分布于体液中,易通过肾小球滤过膜,在肾小管中几乎全部被吸收。本文观察了糖尿病,慢性肾衰及非肾脏感染性疾病的血、尿α_1-MG,β_2-MG含量的变化。现将结果报告如下。 1 材料与方法 1.1病例选择:糖尿病组(DM),男21例,女16例,平均年龄60.4岁。均为非胰岛素依赖型糖尿病患者,肾功能正常,常规尿蛋白定性试验阴性。慢性肾衰组(CRF),男10例,女5例,平均年龄42岁。非肾脏感染组(NKD),男11例,女5例,平均年龄59.2岁,均为慢性支气管炎及下呼吸道感染,无合并肾脏疾病。以上全部病人均为同期住院病人。 1.2检测方法:测定血Scr、BUN,尿白蛋白
Alpha-1 microglobulin (α_1-MG) is a glycoprotein with a molecular weight of 3300 daltons, which is mainly produced in the liver and lymphocytes and is widely distributed in body fluids and easily passes through the glomerular filtration membrane. Almost all are absorbed. In this paper, we observed the changes of blood and urine α_1-MG and β_2-MG in diabetic, chronic renal failure and non-renal infectious diseases. The results reported below. 1 Materials and Methods 1.1 Case Selection: Diabetes Mellitus (DM), 21 males and 16 females, with an average age of 60.4 years old. Are non-insulin-dependent diabetic patients, normal renal function, routine urine protein qualitative test negative. Chronic renal failure group (CRF), 10 males and 5 females, mean age 42 years old. Non-kidney infection group (NKD), 11 males and 5 females, mean age 59.2 years, were chronic bronchitis and lower respiratory tract infection, without renal disease. All of the above patients are inpatients over the same period. 1.2 detection methods: determination of blood Scr, BUN, urinary albumin